Zhao, Y., Villasante-Tezanos, A., Miranda-Morales, E. G., Pappolla, M. A. & Fang, X., Nov 1 2024, In: Journal of Alzheimer's disease : JAD. 102, 1, p. 237-253 17 p.
A new method has been discovered to detect Alzheimer’s disease using a simple blood test. Blood samples from people with and without Alzheimer’s were analyzed using advanced technology to identify tiny molecules linked to the disease. Artificial intelligence helped pinpoint specific molecules that indicate Alzheimer’s with high accuracy. This breakthrough could lead to an easy, non-invasive way to diagnose the disease early, allowing for faster treatment and better patient care.
Pappolla, M. A., Refolo, L., Sambamurti, K., Zambon, D. & Duff, K., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S371-S393
High cholesterol in midlife is linked to a higher risk of Alzheimer’s. Studies suggest cholesterol-lowering drugs may help, but clinical trials show mixed results, possibly due to timing or patient selection. Managing cholesterol early, especially for high-risk individuals, could be key, but more research is needed on other treatment options.
Kaye, A. D., File, C. J., Borne, G. E., Daniel, C. P., Sharma, R., Shekoohi, S. & Pappolla, M. A., Jul 2024, In: Pain physician. 27, 5, p. 273-282 10 p.
Melatonin is known for helping with sleep, but it may also protect the spine from wear and tear. It can reduce swelling, stress on cells, and aging effects in the discs between our backbones. This could lead to new treatments for back pain, helping people feel better without surgery.
Pappolla, M. A., Martins, R. N., Poeggeler, B., Omar, R. A. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S155-S178
Antioxidants are often seen as protective, but treatments using them have not been successful in Alzheimer’s disease. This research highlights challenges such as poor absorption, hidden causes of damage, and overly simple treatment approaches. Understanding these issues could lead to better strategies for slowing the disease’s progression.
Pappolla, M. A., Wu, P., Fang, X., Poeggeler, B., Sambamurti, K., Wisniewski, T. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S395-S416
Stem cell therapy is a new approach to treating brain diseases like stroke, Parkinson’s, and Alzheimer’s by helping the body repair damaged cells. While progress has been made, challenges remain in making these treatments safe and effective. In the future, this research could lead to life-changing breakthroughs.
Pappolla, M. A., Wu, P. & Sambamurti, K., Jan 1 2024, Essentials of Regenerative Medicine in Interventional Pain Management, Second Edition. Springer International Publishing, p. 543-556 14 p.
Stem cell therapy is a promising way to help with brain diseases like stroke, Parkinson’s, and Alzheimer’s by repairing damaged nerves. Although these treatments are still being tested, early results look hopeful. In the future, they could improve brain health, slow aging, and give people better treatment options.
Moreira, P. I., Avila, J., Galimberti, D., Pappolla, M. A., Plascencia-Villa, G., Sorensen, A. A., Zhu, X. & Perry, G., 2024, In: Journal of Alzheimer's disease : JAD. 101, s1, p. S1-S2
Finding effective treatments for Alzheimer’s disease remains a challenge, but new approaches go beyond traditional drug therapies. Strategies like lifestyle changes, brain stimulation, and repurposed medications are being explored to slow the disease. These efforts offer hope for better treatments that may improve memory and quality of life.
Rippee-Brooks, M. D., Wu, W., Dong, J., Pappolla, M., Fang, X. & Bao, X., Mar 2024, In: Pathogens. 13, 3, 240.
Some viruses, including herpes and COVID-19, may play a role in Alzheimer’s disease by affecting brain cells and the immune system. Understanding this connection could help uncover new ways to prevent or slow the disease. If infections contribute to Alzheimer’s, vaccines or antiviral treatments might reduce the risk.
Wu, W., Shen, A., Lee, I., Miranda-Morales, E. G., Spratt, H., Pappolla, M. A., Fang, X. & Bao, X., Nov 21 2023, In: Journal of Alzheimer's Disease. 96, 3, p. 1285-1304 20 p.
Poeggeler, B., Singh, S. K., Sambamurti, K. & Pappolla, M. A., Oct 2023, In: International journal of molecular sciences. 24, 19, 14533.
Poeggeler, B., Singh, S. K., Sambamurti, K. & Pappolla, M. A., Apr 2023, In: International journal of molecular sciences. 24, 8, 7112.
Pappolla, M. A., Carare, R. O., Poeggeler, B., Wisniewski, T. & Sambamurti, K., Sep 2022, In: Current Alzheimer Research. 19, 10, p. 689-693 5 p.
Poeggeler, B., Singh, S. K. & Pappolla, M. A., May 1 2022, In: International journal of molecular sciences. 23, 10, 5455.
Poeggeler, B., Robenek, H. & Pappolla, M. A., Aug 3 2021, In: Frontiers in Pharmacology. 12, 743788.
Pappolla, M. A., Perry, G., Fang, X., Zagorski, M., Sambamurti, K. & Poeggeler, B., Aug 2021, In: Neurobiology of Disease. 156, 105403.
Pappolla, M. A., Manchikanti, L., Candido, K. D., Grieg, N., Seffinger, M., Ahmed, F., Fang, X., Andersen, C. & Trescot, A. M., 2021, In: Pain physician. 24, 2, p. 175-184 10 p.
Manchikanti, L., Atluri, S., Boswell, M. V., Calodney, A. K., Diwan, S., Gupta, S., Kaye, A. D., Knezevic, N. N., Candido, K. D., Abd-Elsayed, A., Pappolla, M. A., Racz, G. B., Sachdeva, H., Sanapati, M. R., Shah, S., Singh, V., Soin, A. & Hirsch, J. A., Jan 24 2021, In: Pain physician. 24, p. S1-S26
Pappolla, M., Manchikanti, L., Andersen, C. R., Greig, N. H., Ahmed, F., Fang, X., Seffinger, M. A. & Trescot, A. M., Jan 1 2019, In: PloS one. 14, 5, p. e0216079
Navani, A., Manchikanti, L., Albers, S. L., Latchaw, R. E., Sanapati, J., Kaye, A. D., Atluri, S., Jordan, S., Gupta, A., Cedeno, D., Vallejo, A., Fellows, B., Knezevic, N. N., Pappolla, M., Diwan, S., Trescot, A. M., Soin, A., Kaye, A. M., Aydin, S. M. & Calodney, A. K. & 10 others, , 2019, In: Pain physician. 22, 1S, p. S1-S74
Sanapati, J., Manchikanti, L., Atluri, S., Jordan, S., Albers, S. L., Pappolla, M. A., Kaye, A. D., Candido, K. D., Pampati, V. & Hirsch, J. A., Nov 2018, In: Pain physician. 21, 6, p. 515-540 26 p.
Pappolla, M. A., Matsubara, E., Vidal, R., Pacheco-Quinto, J., Poeggeler, B., Zagorski, M. & Sambamurti, K., 2018, In: Current Alzheimer Research. 15, 7, p. 637-642 6 p.
Baranello, R. J., Bharani, K. L., Padmaraju, V., Chopra, N., Lahiri, D. K., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Oct 1 2015, In: Current Alzheimer Research. 12, 1, p. 32-46 15 p.
R J Baranello, K L Bharani, V Padmaraju, N Chopra, D K Lahiri, N H Greig, ...
Current Alzheimer Research 12 (1), 32-46
Pappolla, M., Sambamurti, K., Vidal, R., Pacheco-Quinto, J., Poeggeler, B. & Matsubara, E., Nov 2014, In: Neurobiology of Disease. 71, p. 215-219 5 p.
Barnwell, E., Padmaraju, V., Baranello, R., Pacheco-Quinto, J., Crosson, C., Ablonczy, Z., Eckman, E., Eckman, C. B., Ramakrishnan, V., Greig, N. H., Pappolla, M. A. & Sambamurti, K., Mar 21 2014, In: PloS one. 9, 3, e91531.
Pinnix, I., Ghiso, J. A., Pappolla, M. A. & Sambamurti, K., May 2013, In: American Journal of Geriatric Psychiatry. 21, 5, p. 474-483 10 p.
Sambamurti, K., Greig, N. H., Utsuki, T., Barnwell, E. L., Sharma, E., Mazell, C., Bhat, N. R., Kindy, M. S., Lahiri, D. K. & Pappolla, M. A., May 2011, In: Journal of neurochemistry. 117, 3, p. 359-374 16 p.
Durand, G., Poeggeler, B., Ortial, S., Polidori, A., Villamena, F. A., Böker, J., Hardeland, R., Pappolla, M. A. & Pucci, B., Jul 8 2010, In: Journal of medicinal chemistry. 53, 13, p. 4849-4861 13 p.
Poeggeler, B., Sambamurti, K., Siedlak, S. L., Perry, G., Smith, M. A. & Pappolla, M. A., 2010, In: PloS one. 5, 4, e10206.
Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A., Rao, K. J., Pappolla, M. A. & Sambamurti, K., 2010, In: Journal of Alzheimer's Disease. 20, 4, p. 1243-1253 11 p.
D Zambón, M Quintana, P Mata, R Alonso, J Benavent, F Cruz-Sánchez, ...
The American journal of medicine 123 (3), 267-274
B Poeggeler, C Schulz, MA Pappolla, E Bodó, S Tiede, H Lehnert, R Paus
Experimental Dermatology 19 (1), 12-18
Siedlak, S. L., Casadesus, G., Webber, K. M., Pappolla, M. A., Atwood, C. S., Smith, M. A. & Perry, G., 2009, In: Free Radical Research. 43, 2, p. 156-164 9 p.
C Venugopal, CM Demos, KS Jagannatha Rao, MA Pappolla, ...
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …
Pappolla, M. A., Dec 9 2008, In: Neurology. 71, 24, p. 2020; author reply 2020-2021
Sambamurti, K., Pappolla, M. A. & Rao, K. S. J., 2008, In: Journal of Alzheimer's Disease. 14, 2, p. 175-177 3 p.
Matsubara, E., Tsuchiya, A., Minami, N., Nishino, I., Pappolla, M. A., Shoji, M. & Abe, K., Jul 2007, In: European Journal of Neurology. 14, 7, p. 819-822 4 p.
Durand, G., Poeggeler, B., Böker, J., Raynal, S., Polidori, A., Pappolla, M. A., Hardeland, R. & Pucci, B., Aug 23 2007, In: Journal of medicinal chemistry. 50, 17, p. 3976-3979 4 p.
Venugopal, C., Pappolla, M. A. & Sambamurti, K., Dec 2007, In: Neurochemical Research. 32, 12, p. 2225-2234 10 p.
Ortial, S., Durand, G., Poeggeler, B., Polidori, A., Pappolla, M. A., Böker, J., Hardeland, R. & Pucci, B., May 4 2006, In: Journal of medicinal chemistry. 49, 9, p. 2812-2820 9 p.
J Pacheco-Quinto, EBR de Turco, S DeRosa, A Howard, F Cruz-Sanchez, ...
Neurobiology of disease 22 (3), 651-656
G Casadesus, KM Webber, CS Atwood, MA Pappolla, G Perry, RL Bowen, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1762 (4), 447-452
Lukiw, W. J., Pappolla, M., Pelaez, R. P. & Bazan, N. G., Jun 2005, In: Cellular and Molecular Neurobiology. 25, 3-4, p. 475-483 9 p.
Poeggeler, B., Durand, G., Polidori, A., Pappolla, M. A., Vega-Naredo, I., Coto-Montes, A., Böker, J., Hardeland, R. & Pucci, B., Nov 2005, In: Journal of neurochemistry. 95, 4, p. 962-973 12 p.
Reiter, R. J., Tan, D. X. & Pappolla, M. A., 2004, In: Annals of the New York Academy of Sciences. 1035, p. 179-196 18 p.
Petanceska, S. S., DeRosa, S., Sharma, A., Diaz, N., Duff, K., Tint, S. G., Refolo, L. M. & Pappolla, M., 2003, In: Journal of Molecular Neuroscience. 20, 3, p. 395-406 12 p.
Pappolla, M. A., Petanceska, S., Refolo, L. & Bazan, N. G., 2003, Membrane Lipid Signaling in Aging and Age-Related Disease. Elsevier, p. 163-175 13 p. (Advances in Cell Aging and Gerontology; vol. 12).
Matsubara, E., Bryant-Thomas, T., Pacheco, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz-Sanchez, F., Chyan, Y. J., Smith, M. A., Perry, G., Chain, D. G., Neria, E., Shoji, M., Abe, K., Leone, A., Grundke-Iqbal, I., Wilson, G. L., Ghiso, J., Williams, C. & Refolo, L. M. & 1 others, , Sep 2003, In: Journal of neurochemistry. 86, 5, p. 1312 1 p.
L Marlow, M Cain, MA Pappolla, K Sambamurti
Journal of Molecular Neuroscience 20, 233-239
MA Pappolla, TK Bryant-Thomas, D Herbert, J Pacheco, M Fabra Garcia, ...
Neurology 61 (2), 199-205
E Matsubara, T Bryant‐Thomas, J Pacheco Quinto, TL Henry, ...
Journal of Neurochemistry 85 (5), 1101-1108
YZ Wadghiri, EM Sigurdsson, M Sadowski, JI Elliott, Y Li, H Scholtzova, ...
Magnetic Resonance in Medicine: An Official Journal of the International …
SS Petanceska, S DeRosa, V Olm, N Diaz, A Sharma, T Thomas-Bryant, ...
Journal of Molecular Neuroscience 19, 155-161
PE Bendheim, B Poeggeler, E Neria, V Ziv, MA Pappolla, DG Chain
Journal of molecular neuroscience 19, 213-217
B Poeggeler, L Miravalle, MG Zagorski, T Wisniewski, YJ Chyan, Y Zhang, ...
Biochemistry 40 (49), 14995-15001
DP Hopkins, PA Briss, CJ Ricard, CG Husten, VG Carande-Kulis, ...
American journal of preventive medicine 20 (2), 16-66
LM Refolo, MA Pappolla, J LaFrancois, B Malester, SD Schmidt, ...
Neurobiology of disease 8 (5), 890-899
LM Refolo, MA Pappolla, B Malester, J LaFrancois, T Bryant-Thomas, ...
Neurobiology of disease 7 (4), 321-331
A Nunomura, G Perry, MA Pappolla, RP Friedland, K Hirai, S Chiba, ...
Journal of Neuropathology & Experimental Neurology 59 (11), 1011-1017
MA Pappolla, YJ Chyan, B Poeggeler, B Frangione, G Wilson, J Ghiso, ...
Journal of neural transmission 107, 203-231
RA Omar, YJ Chyan, AC Andorn, B Poeggeler, NK Robakis, MA Pappolla
Journal of Alzheimer's Disease 1 (3), 139-145
A Nunomura, G Perry, MA Pappolla, R Wade, K Hirai, S Chiba, MA Smith
Journal of Neuroscience 19 (6), 1959-1964
YJ Chyan, B Poeggeler, RA Omar, DG Chain, B Frangione, J Ghiso, ...
Journal of Biological Chemistry 274 (31), 21937-21942
MA Smith, K Hirai, K Hsiao, MA Pappolla, PLR Harris, SL Siedlak, ...
Journal of neurochemistry 70 (5), 2212-2215
M Pappolla, P Bozner, C Soto, H Shao, NK Robakis, M Zagorski, ...
Journal of Biological Chemistry 273 (13), 7185-7188
MA Pappolla, YJ Chyan, RA Omar, K Hsiao, G Perry, MA Smith, P Bozner
The American journal of pathology 152 (4), 871
MA Pappolla, M Sos, RA Omar, RJ Bick, DLM Hickson-Bick, RJ Reiter, ...
Journal of Neuroscience 17 (5), 1683-1690
P Bozner, V Grishko, SP LeDoux, GL Wilson, YC Chyan, MA Pappolla
Journal of Neuropathology & Experimental Neurology 56 (12), 1356-1362
RJ Reiter, JM Guerrero, G Escames, MA Pappolla, ...
Annals of the New York Academy of Sciences 825 (1), 70-78
MA Pappolla, RA Omar, KS Kim, NK Robakis
The American journal of pathology 140 (3), 621
K Sambamurti, J Shioi, JP Anderson, MA Pappolla, NK Robakis
Journal of neuroscience research 33 (2), 319-329
JA Holland, KA Pritchard, MA Pappolla, MS Wolin, NJ Rogers, ...
Journal of cellular physiology 143 (1), 21-25
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